Ativan is a famous drug from the group of benzodiazepine derivatives, which are widely used for the treatment of a wide spectrum of mental health problems from sleeping disorders to epileptic seizures. According to the instructions for use, Ativan also has a calming and relaxing effect.
The drug is applicable for neurosis and anxiety states accompanied by somatic disorders, insomnia and panic attacks. It also has an anticonvulsant and muscle relaxant effect.
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PHARMACODYNAMICS AND PHARMACOKINETICS
Pharmachologic effect of Lorazepam is due to its similarity with gamma-aminobutyric acid (GABA). Lorazepam belongs to the category of benzodiazepine derivatives and affects the CNS structures, responsible for the regulation of emotional activity (these are limbic system and hypothalamus). The drug provides the flow of chlorine into the excited neuron, which in turn stabilizes neuron.
Lorazepam acts on the body as:
- sleeping drug
- muscle relaxant
Active substance is well absorbed from the digestive tract, reaching its maximum concentration in the patient’s blood 2 hours later.
INDICATIONS AND CONTRAINDICATIONS
Ativan is widely used in the modern medicine for the treatment of such states and mental illnesses:
- various phobias
- psychosomatic disorders
- panic attacks
- obsessive-compulsive syndrome
- mental disorders related to injuries
- behavioral disorders
- sleep disorders
- headache caused by increased emotional stress and tension
- nervousness and anxiety
- consequences of the shock experienced
- sickness and vomiting, triggered by a course of chemotherapy
Also, Ativan can be used as a component of combination therapy during the treatment of chronic alcohol addiction. Sometimes, it is prescribed in combination with analgesic medicines to prepare the patients for operative or diagnostic interventions.
Ativan is used in medicine to eliminate the symptoms of mental diseases:
- increased anxiety
- alcohol delirium
Ativan is a powerful substance; therefore, it is strictly forbidden to the patients, which have the following concomitant diseases and conditions:
- hypersensitivity to the active substance or auxiliary components
- intolerance to other drugs with a similar mechanism of action
- intoxication with substances depressing the central nervous system
- breathing problems
- liver failure
- apnea syndrome
- addiction to drugs, nicotine and alcohol (except withdrawal syndrome)
- alcohol intoxication
- acute renal failure
The use of Ativan is strictly forbidden to pregnant and breastfeeding women. If the use of Lorazepam is critical for the mother’s health, she should stop breastfeeding for the time of therapy with this medicine. Also, this medication is forbidden to the minor patients. Elderly patients must take Lorazepam with great caution and closely monitor the body’s response to the drug.
The use of Ativan can affect the patient’s reaction rate. Therefore, during the treatment, you need to refrain from driving and managing other complex mechanisms and limit the work requiring caution.
According to the instructions for use, you should start the treatment with Ativan with the lowest effective dose, and the course must not be long. With a large dosage and long course, such substances can make the patient addicted. In case of abrupt withdrawal of Ativan, chances are that the patient may experience withdrawal or rebound syndrome; therefore, it is necessary to stop the course by gradually reducing the drug dose.